/  Blog   /  Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis [ME/CFS]

Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis [ME/CFS]

CFS/ME is defined as a long-standing, severe, disabling fatigue without demonstrable muscle weakness. Leading health organizations recognize this as a serious, long-term illness possibly caused by a disruption in how the immune system responds to infection or stress. It shares many characteristics with autoimmune diseases like rheumatoid arthritis but without apparent signs of tissue damage.

Myalgic Encephalomyelitis literally means acute inflammation in the brain and the spinal cord along with muscle pain. Chronic fatigue must not be confused with ME/CFS because the “fatigue” of ME/CFS represents pathophysiological exhaustion and is only one of many symptoms.
Chronic Fatigue Syndrome also now known as Myalgic Encephalomyelitis is classified as a neurological disease in the World Health Organization’s International Classification of Diseases (ICD).

By now most of you must be guessing that you are one of those sufferers, trust me so did I! But we actually might not be, as the fatigue termed here is so life tasking that it usually only gets worse, as even the mildest activity, like brushing your teeth, can lead to a debilitating fatigue, the core symptom of the disease.

ETIOLOGY

The etiology is controversial and the precise cause remains unknown. A few probable causes are:

  1. Psychological factors
  2. Various immunologic abnormalities have been reported, they include low levels of IgG, decreased lymphocytic proliferation, low levels of interferon- γ in response to mitogens, and poor cytotoxicity of natural killer cells.
  3. Other prodromal events include immunization, anesthetics, physical trauma, exposure to environmental pollutants, chemicals and heavy metals, and rarely blood transfusions.
  4. Some have abnormal circulating autoantibodies and immune complexes.
  5. A chronic viral infection such as Lyme disease, mononucleosis, influenza, Q fever, Ross River virus, parvovirus.
  6. Epstein- Barr virus also, however the immunologic markers are not so sensitive or specific.
  7. Other possible but unknown viral causes include rubella, HIV, Enteroviruses, Human herpes virus 6 and human T-cell lymphotropic virus.
  8. Other proposed mechanism involves impaired activation of the Hypothalamic-Pituitary-Adrenal Axis in the CFS patients.
  9. Abnormal levels of neurotransmitters, inadequate cerebral circulation, prolonged bed rest, undernutrition, and elevated levels of ACE.
  10. In addition to infectious causes, a genetic predisposition may be considered when more than one separated family member is afflicted.

SYMPTOMS & SIGNS

Onset is usually abrupt and many patients report an initial viral-like illness.

With the possible mentioned symptoms below:

  • Minimal exertion, patients tend to “crash” or “collapse” and may require days, weeks or longer rebound.
  • Brain function is often described as “foggy,” causing problems with memory, quick thinking and attention to detail.
  • Muscle and joint pain unrelated to an injury is a common accompaniment.
  • Headaches those are new or worse than before.
  • Some have tender lymph nodes in the neck or armpits,
  • A frequent sore throat, chills and night sweats,
  • Allergic sensitivities
  • Or digestive problems.
  • Sleep dysfunction.

However no organomegaly is present.

 

 

Response to Exercise Healthy People ME/CFS Patients
Sense of well-being Invigorating, anti- depressant effect Feel malaise, fatigue and worsening of symptoms
Resting heart rate Normal Elevated
Heart rate at maximum workload Elevated Reduced heart rate
Maximum oxygen uptake Elevated Approximately 1⁄2 of sedentary controls
Age-predicted target heart rate Can achieve it Often cannot achieve it and should not be forced
Cardiac output Increased Sub-optimal level
Cerebral blood flow Increased Decreased
Cerebral oxygen Increased Decreased
Body temperature Increased Decreased
Respiration Breathing irregularities: shortness of breath, shallow breathing
Cognitive processing Normal, more alert Impaired
Recovery period Short Often 24 hours but can last days or weeks
Oxygen delivery to the muscles Increased Impaired
Gait kinematics Normal Gait abnormalities

 

DIAGNOSIS

There is no definitive diagnostic test, diagnosis is by clinical criteria only. However, because of all the more possible theories of this exist and one should confine to a single criteria for an individual unless it’s for an epidemic.

A reasonable assessment includes CBP and electrolytes measure, ESR, and thyroid stimulating hormone. In some cases X-Ray and tests for viral infections based on the individual.

Correctly diagnosing ME/CFS, hard enough in adults, is even more of a challenge in children and adolescents, whose problems both within and outside of school can be misattributed to a neurological, learning or psychosocial disorder or simply laziness.Youngsters may also get the syndrome and require a team approach with flexible educational resources and demands suited to each child’s ability to meet them.

MANAGEMENT

The patient must be thoroughly informed of the current understanding of CFS and the daily functions impairment, along with the general advice for the disease management.

Patients with CFS have benefitted from a comprehensive multidisciplinary intervention, including optimal medical management, and implementing comprehensive, cognitive-behavioral treatment program. At present, cognitive-behavioral therapy and graded exercise are the treatments of choice for the patients with chronic fatigue syndrome. Although a few patients are cured, the treatment basis is substantial.

  • Cognitive-behavioral therapy, the emphasis is on self-help and aiming to change perceptions and behaviors that may perpetuate symptoms and disability, is helpful.
  • Graded exercise emphasizes on improving functional work capacity and physical function. Studies show an altered immune response to exercise in patients with CFS.

In addition, the clinicians sympathetic listening and explanatory responses can help overcome the patient’s frustrations and debilitation by this still mysterious illness. All patients should be encouraged to engage in normal activities to the extent possible and should be reassured that full recovery is eventually possible in most cases.

SOURCES:

Current Medical Diagnosis & Treatment, Edition 2017, Common symptoms – Pg.No. 37-39
Harrisons Manual Of Medicine, 19th Edition, Section 3, Pg. No. 134
The Merck Manual, 19th Edition, Chapter 348, Syndromes of Uncertain Origin, Pg. No. 3442-3443
https://www.independent.co.uk/life-style/health-and-families/new-recognition-for-chronic-fatigue-a8081751.html
http://angliameaction.org.uk/docs/CanadianOverviewUK.pdf
https://academic.oup.com/jcem/article-abstract/73/6/1224/2653522

By: MAHEK SINGH
2nd Year, BHMS.

xosotin chelseathông tin chuyển nhượngcâu lạc bộ bóng đá arsenalbóng đá atalantabundesligacầu thủ haalandUEFAevertonxosofutebol ao vivofutemaxmulticanaisonbethttps://bsport.fithttps://onbet88.ooohttps://i9bet.bizhttps://hi88.ooohttps://okvip.athttps://f8bet.athttps://fb88.cashhttps://vn88.cashhttps://shbet.atbóng đá world cupbóng đá inter milantin juventusbenzemala ligaclb leicester cityMUman citymessi lionelsalahnapolineymarpsgronaldoserie atottenhamvalenciaAS ROMALeverkusenac milanmbappenapolinewcastleaston villaliverpoolfa cupreal madridpremier leagueAjaxbao bong da247EPLbarcelonabournemouthaff cupasean footballbên lề sân cỏbáo bóng đá mớibóng đá cúp thế giớitin bóng đá ViệtUEFAbáo bóng đá việt namHuyền thoại bóng đágiải ngoại hạng anhSeagametap chi bong da the gioitin bong da lutrận đấu hôm nayviệt nam bóng đátin nong bong daBóng đá nữthể thao 7m24h bóng đábóng đá hôm naythe thao ngoai hang anhtin nhanh bóng đáphòng thay đồ bóng đábóng đá phủikèo nhà cái onbetbóng đá lu 2thông tin phòng thay đồthe thao vuaapp đánh lô đềdudoanxosoxổ số giải đặc biệthôm nay xổ sốkèo đẹp hôm nayketquaxosokq xskqxsmnsoi cầu ba miềnsoi cau thong kesxkt hôm naythế giới xổ sốxổ số 24hxo.soxoso3mienxo so ba mienxoso dac bietxosodientoanxổ số dự đoánvé số chiều xổxoso ket quaxosokienthietxoso kq hôm nayxoso ktxổ số megaxổ số mới nhất hôm nayxoso truc tiepxoso ViệtSX3MIENxs dự đoánxs mien bac hom nayxs miên namxsmientrungxsmn thu 7con số may mắn hôm nayKQXS 3 miền Bắc Trung Nam Nhanhdự đoán xổ số 3 miềndò vé sốdu doan xo so hom nayket qua xo xoket qua xo so.vntrúng thưởng xo sokq xoso trực tiếpket qua xskqxs 247số miền nams0x0 mienbacxosobamien hôm naysố đẹp hôm naysố đẹp trực tuyếnnuôi số đẹpxo so hom quaxoso ketquaxstruc tiep hom nayxổ số kiến thiết trực tiếpxổ số kq hôm nayso xo kq trực tuyenkết quả xổ số miền bắc trực tiếpxo so miền namxổ số miền nam trực tiếptrực tiếp xổ số hôm nayket wa xsKQ XOSOxoso onlinexo so truc tiep hom nayxsttso mien bac trong ngàyKQXS3Msố so mien bacdu doan xo so onlinedu doan cau loxổ số kenokqxs vnKQXOSOKQXS hôm naytrực tiếp kết quả xổ số ba miềncap lo dep nhat hom naysoi cầu chuẩn hôm nayso ket qua xo soXem kết quả xổ số nhanh nhấtSX3MIENXSMB chủ nhậtKQXSMNkết quả mở giải trực tuyếnGiờ vàng chốt số OnlineĐánh Đề Con Gìdò số miền namdò vé số hôm nayso mo so debach thủ lô đẹp nhất hôm naycầu đề hôm naykết quả xổ số kiến thiết toàn quốccau dep 88xsmb rong bach kimket qua xs 2023dự đoán xổ số hàng ngàyBạch thủ đề miền BắcSoi Cầu MB thần tàisoi cau vip 247soi cầu tốtsoi cầu miễn phísoi cau mb vipxsmb hom nayxs vietlottxsmn hôm naycầu lô đẹpthống kê lô kép xổ số miền Bắcquay thử xsmnxổ số thần tàiQuay thử XSMTxổ số chiều nayxo so mien nam hom nayweb đánh lô đề trực tuyến uy tínKQXS hôm nayxsmb ngày hôm nayXSMT chủ nhậtxổ số Power 6/55KQXS A trúng roycao thủ chốt sốbảng xổ số đặc biệtsoi cầu 247 vipsoi cầu wap 666Soi cầu miễn phí 888 VIPSoi Cau Chuan MBđộc thủ desố miền bắcthần tài cho sốKết quả xổ số thần tàiXem trực tiếp xổ sốXIN SỐ THẦN TÀI THỔ ĐỊACầu lô số đẹplô đẹp vip 24hsoi cầu miễn phí 888xổ số kiến thiết chiều nayXSMN thứ 7 hàng tuầnKết quả Xổ số Hồ Chí Minhnhà cái xổ số Việt NamXổ Số Đại PhátXổ số mới nhất Hôm Nayso xo mb hom nayxxmb88quay thu mbXo so Minh ChinhXS Minh Ngọc trực tiếp hôm nayXSMN 88XSTDxs than taixổ số UY TIN NHẤTxs vietlott 88SOI CẦU SIÊU CHUẨNSoiCauVietlô đẹp hôm nay vipket qua so xo hom naykqxsmb 30 ngàydự đoán xổ số 3 miềnSoi cầu 3 càng chuẩn xácbạch thủ lônuoi lo chuanbắt lô chuẩn theo ngàykq xo-solô 3 càngnuôi lô đề siêu vipcầu Lô Xiên XSMBđề về bao nhiêuSoi cầu x3xổ số kiến thiết ngày hôm nayquay thử xsmttruc tiep kết quả sxmntrực tiếp miền bắckết quả xổ số chấm vnbảng xs đặc biệt năm 2023soi cau xsmbxổ số hà nội hôm naysxmtxsmt hôm nayxs truc tiep mbketqua xo so onlinekqxs onlinexo số hôm nayXS3MTin xs hôm nayxsmn thu2XSMN hom nayxổ số miền bắc trực tiếp hôm naySO XOxsmbsxmn hôm nay188betlink188 xo sosoi cầu vip 88lô tô việtsoi lô việtXS247xs ba miềnchốt lô đẹp nhất hôm naychốt số xsmbCHƠI LÔ TÔsoi cau mn hom naychốt lô chuẩndu doan sxmtdự đoán xổ số onlinerồng bạch kim chốt 3 càng miễn phí hôm naythống kê lô gan miền bắcdàn đề lôCầu Kèo Đặc Biệtchốt cầu may mắnkết quả xổ số miền bắc hômSoi cầu vàng 777thẻ bài onlinedu doan mn 888soi cầu miền nam vipsoi cầu mt vipdàn de hôm nay7 cao thủ chốt sốsoi cau mien phi 7777 cao thủ chốt số nức tiếng3 càng miền bắcrồng bạch kim 777dàn de bất bạion newsddxsmn188betw88w88789bettf88sin88suvipsunwintf88five8812betsv88vn88Top 10 nhà cái uy tínsky88iwinlucky88nhacaisin88oxbetm88vn88w88789betiwinf8betrio66rio66lucky88oxbetvn88188bet789betMay-88five88one88sin88bk88xbetoxbetMU88188BETSV88RIO66ONBET88188betM88M88SV88Jun-68Jun-88one88iwinv9betw388OXBETw388w388onbetonbetonbetonbet88onbet88onbet88onbet88onbetonbetonbetonbetqh88mu88Nhà cái uy tínpog79vp777vp777vipbetvipbetuk88uk88typhu88typhu88tk88tk88sm66sm66me88me888live8live8livesm66me88win798livesm66me88win79pog79pog79vp777vp777uk88uk88tk88tk88luck8luck8kingbet86kingbet86k188k188hr99hr99123b8xbetvnvipbetsv66zbettaisunwin-vntyphu88vn138vwinvwinvi68ee881xbetrio66zbetvn138i9betvipfi88clubcf68onbet88ee88typhu88onbetonbetkhuyenmai12bet-moblie12betmoblietaimienphi247vi68clupcf68clupvipbeti9betqh88onb123onbefsoi cầunổ hũbắn cáđá gàđá gàgame bàicasinosoi cầuxóc đĩagame bàigiải mã giấc mơbầu cuaslot gamecasinonổ hủdàn đềBắn cácasinodàn đềnổ hũtài xỉuslot gamecasinobắn cáđá gàgame bàithể thaogame bàisoi cầukqsssoi cầucờ tướngbắn cágame bàixóc đĩaAG百家乐AG百家乐AG真人AG真人爱游戏华体会华体会im体育kok体育开云体育开云体育开云体育乐鱼体育乐鱼体育欧宝体育ob体育亚博体育亚博体育亚博体育亚博体育亚博体育亚博体育开云体育开云体育棋牌棋牌沙巴体育买球平台新葡京娱乐开云体育mu88qh88